The mozillazine firefox tuning guide is pretty detailed. Another guide is at tweakfactor. An extension I've not tried myself, helps tweak Firefox settings
I like the concept - I generally find Firefox slow and it takes up at least 60 MB of RAM, with millions of page faults. Still use it though - primarily, I think, because of the drag-and-drop opening of tabs.
For some reason I am unable to view quicktime videos properly within Firefox and have to switch to IE for any video-rich page. Any tips?
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